Key Health Benefits

Use Case	Summary of Findings	PubMed Link
Cholesterol and Lipid Profile Improvement	A meta-analysis of 8 RCTs found that niacin supplementation significantly improved lipid profiles – lowering total cholesterol, LDL, and triglycerides while raising HDL levels.	PubMed
Energy Metabolism and NAD⁺ Synthesis	Niacin serves as a precursor for NAD⁺, crucial in cellular energy metabolism. In patients with mitochondrial myopathy, high-dose niacin therapy (up to 1 g/day) markedly increased NAD⁺ levels (blood NAD⁺ up to 8-fold) and enhanced muscle mitochondrial function.	PubMed
Skin Health and Dermatitis Prevention (Pellagra)	Niacin is essential for skin health. Pellagra – the disease caused by niacin deficiency – leads to severe dermatitis, and niacin supplementation has a dramatic curative effect, resolving the characteristic skin lesions.	PubMed
Cardiovascular Endothelial Function	Niacin can help improve vascular endothelial function. A systematic review and meta-analysis of RCTs showed that niacin therapy significantly improved endothelium-dependent dilation, with an ~2% absolute increase in flow-mediated dilation (FMD).	PubMed
Cognitive Support and Neuroprotection	Higher niacin intake has been linked to better cognitive health. In a large prospective study, older adults with the highest niacin intake had ~70% lower risk of Alzheimer’s disease and significantly less cognitive decline over ~6 years. The authors concluded that dietary niacin may protect against age-related cognitive decline.	PubMed

Dosage Recommendation

Goal	Dosage
General Health & RDA	14 mg NE (men) / 14 mg NE (women) daily
Cholesterol Management	42 mg/day of sustained-release niacin, split into 2–3 doses, under medical supervision to manage lipids.
Energy & Metabolic Support	14 mg/day as part of a B-complex to support NAD⁺ pools and energy metabolism.
Skin & Dermatitis (Pellagra)	14 mg/day until deficiency symptoms resolve, then maintain with RDA levels.
Neuroprotective Support	14 mg/day, which in studies increased brain NAD⁺ and activated sirtuins; for long-term cognitive support.

Supplement Facts

NUTRITIONAL INFORMATION
Serving Size: 1 veg. Capsule
	Amt. per Serving	% RDA Men	% RDA Women
Niacin (Vitamin B3)	14mg	77.77	100
Ingredients: Nicotinic Acid (Vitamin B3), Bulking Agent INS 460 (i), Anticaking Agent INS 341(iii) & Vegetable Capsule Shell (HPMC) (INS 464)

When Will I See Results?

Goal	Expected Timeline
Lipid Improvements	4–8 weeks for measurable increases in HDL-C and reductions in LDL-C/triglycerides.
Energy & Fatigue	1–2 weeks for improved exercise tolerance and reduced fatigue once NAD⁺ pools rise.
Skin Lesion Resolution	2–4 weeks to see healing of dermatitis or acne lesions with adequate dosing.
Endothelial Function	4–6 weeks for better vasodilation and reduced inflammatory markers.
Cognitive Effects	8–12 weeks for enhanced mental clarity and neuroprotective benefits via sirtuin activation.

How to Maximize Results

Goal	Synergistic Stack / Habit
Cholesterol Control	Niacin + Omega-3 fatty acids + Soluble fiber (psyllium) to further improve lipid profile and reduce inflammation.
Energy Metabolism	Niacin + B-Complex (B2, B6, B12) + CoQ₁₀ to support mitochondrial redox reactions and ATP production.
Skin Health	Niacin + Zinc (15 mg) + Vitamin A (beta-carotene) to promote epidermal repair and reduce inflammation.
Vascular Protection	Niacin + L-arginine + Antioxidants (vitamin C, E) to enhance nitric oxide and counteract oxidative stress.
Neuroprotection	Niacin + Resveratrol + Magnesium to synergistically activate sirtuins and support neuronal resilience.

What to Avoid

Substance / Condition	Why to Avoid	Spacing Tip / Advice
Alcohol (Excessive)	Can exacerbate flushing and liver stress during high-dose niacin therapy.	Limit alcohol intake; avoid around niacin dosing times.
Hot Beverages & Spicy Foods	May worsen niacin flushing reactions (cutaneous vasodilation).	Take with food and a full glass of water; consider aspirin 30 min prior to reduce flushing.
Hepatotoxic Drugs	High-dose niacin can raise liver enzymes; avoid combining with other hepatotoxic medications.	Monitor liver function; consult healthcare provider if on other liver-active drugs.
Statins (without supervision)	Combining high-dose niacin with statins may increase risk of myopathy.	Use under physician guidance; monitor for muscle pain/weakness.
Uncontrolled Diabetes	Niacin can worsen glycemic control in some diabetics.	Monitor blood glucose closely; adjust diabetes medications as needed under medical advice.

Third Party NABL Lab Report

Third Party NABL Lab Report for Niacin Vitamin B3 :

 

Click here to view the report