Manganese Gluconate - Hypoallergenic Trace Mineral Supplement for Connective Tissue and Bones - 120 Capsules
100% Honest Claims with No False Promise.
Key Health Benefits
Use Case | Summary of Findings | PubMed Link |
---|---|---|
Bone and connective tissue formation | Manganese is crucial for bone and connective tissue development. In an animal study, manganese supplementation significantly increased bone mineral density (spine and femur) and elevated osteocalcin (a bone formation marker). Additionally, manganese acts as a cofactor for glycosyltransferase enzymes that synthesize proteoglycans, which are essential for healthy cartilage and bone matrix formation. | PubMed |
Antioxidant defense (Mn-SOD activity) | Manganese is an integral component of mitochondrial superoxide dismutase (Mn-SOD), a key antioxidant enzyme. Manganese deficiency leads to reduced Mn-SOD activity and increased oxidative stress, whereas manganese supplementation restores Mn-SOD activity and enhances antioxidant defense. For example, manganese-supplemented mice showed increased Mn-SOD activity in tissues (reversing deficits seen with low Mn), highlighting manganese’s role in protecting cells from oxidative damage. | PubMed |
Wound healing and collagen cross-linking | Manganese aids wound repair by contributing to collagen production and cross-linking. It is required to activate prolidase, an enzyme that provides proline for collagen synthesis in skin cells. A lack of available manganese can impair this process; indeed, a genetic disorder (prolidase deficiency) characterized by aberrant manganese metabolism causes poor wound healing. These findings underscore that adequate manganese is necessary for normal collagen formation and tissue healing. | PubMed |
Cartilage health and osteoarthritis support | Manganese contributes to cartilage integrity and joint health. In a randomized trial of patients with degenerative joint disease, a supplement combining glucosamine, chondroitin, and manganese ascorbate significantly relieved knee osteoarthritis pain and improved functional scores compared to placebo. This suggests that manganese (as part of the combination) supports cartilage repair and may help mitigate osteoarthritis symptoms. | PubMed |
Glucose and lipid metabolism regulation | Manganese is involved in carbohydrate and lipid metabolism as a cofactor for multiple enzymes (e.g. in gluconeogenesis and cholesterol metabolism). Animal studies indicate that insufficient manganese can disrupt metabolic homeostasis — for instance, manganese deficiency impairs glucose tolerance and alters lipid profiles. Conversely, research in diabetic models shows that manganese supplementation can improve glucose tolerance and reduce oxidative stress, supporting a role for manganese in healthy blood sugar and lipid regulation. | PubMed |
Dosage Recommendation
Goal/Use Case | Capsules per Day |
---|---|
General Deficiency Prevention | 1 capsule (providing 4 mg elemental Mn) daily with a meal |
Bone & Connective Tissue Support | 1–2 capsules (4–8 mg Mn) daily, split morning and evening |
Antioxidant & Cellular Protection | 1 capsule daily, ideally with antioxidant-rich foods |
Joint & Cartilage Health | 2 capsules daily in combination with collagen or chondroitin |
Metabolic & Glucose Support | 1 capsule daily with breakfast |
Supplement Facts
NUTRITIONAL INFORMATION | ||
Serving Size: 1 veg. Capsule | ||
Amt. per Serving | % RDA | |
Manganese (From Manganese gluconate) | 4 mg | 100 |
Ingredients: Manganese Gluconate (12%), Bulking Agent INS 460 (i) & Vegetable Capsule Shell (HPMC) (INS 464) |
More Details
Support Your Skeletal Health with Manganese Gluconate
Enhance your wellness routine with our Manganese Gluconate, a hypoallergenic trace mineral supplement designed to promote optimal skeletal health and support your body's connective tissues and bones.
Key Features:
- Skeletal Health Support: Activates and synthesizes vital enzymes and nutrients essential for maintaining strong bones.
- Connective Tissue & Bone Health: Aids in the upkeep of healthy structural tissue and cellular integrity.
- Physiological Support: Catalyzes the utilization of biotin, thiamin, and ascorbic acid; plays a crucial role in synthesizing fatty acids and cholesterol.
- Premium Quality: Made with high-quality ingredients sourced from trusted suppliers and manufactured under strict quality control.
Hypoallergenic:** Free from common allergens such as wheat, eggs, tree nuts, peanuts, gluten, and artificial additives.
Why Choose Manganese Gluconate?
Manganese is not just important for skeletal development, but it also influences the synthesis of mucopolysaccharides and is necessary for detoxification processes in the body. With our supplement, you can support your body's natural functions while ensuring you are getting a quality product that prioritizes your health.
The HealthyHey Difference:
At HealthyHey, we believe in transparency and quality. Our products are free from unnecessary fillers, binders, and preservatives, allowing you to focus on what truly matters—your health and well-being.
Experience the benefits of Manganese Gluconate for yourself and take a step towards improved skeletal and connective tissue health today!
When Will I See Results?
Outcome | Expected Timeline |
---|---|
Bone Density & Cartilage Integrity | 12–16 weeks for measurable improvements in bone markers |
Antioxidant Enzyme Activity | 4–8 weeks for increased Mn-SOD activity and reduced oxidative markers |
Wound Healing Rate | 2–4 weeks for accelerated wound closure in supportive protocols |
Joint Comfort in OA | 8–12 weeks for reduced pain and stiffness scores |
Glucose & Lipid Regulation | 4–8 weeks for modest improvements in fasting glucose and lipids |
How to Maximize Results
Goal | Synergistic Stack & Habits |
---|---|
Bone & Cartilage Support | Mn Gluconate + Vitamin D ₃ + Calcium + Vitamin K₂ |
Antioxidant Defense | Mn Gluconate + Selenium + Glutathione precursors (NAC, glycine) |
Wound Healing & Collagen | Mn Gluconate + Vitamin C + Zinc + Protein-rich diet |
Joint Health | Mn Gluconate + Glucosamine + Chondroitin + Omega-3 (EPA/DHA) |
Metabolic Health | Mn Gluconate + Chromium Picolinate + Alpha-lipoic acid + Balanced low-GI meals |
What to Avoid
Substance / Condition | Why to Avoid | Advice |
---|---|---|
High-Dose Iron Supplements | Iron competes with Mn for absorption | Space iron and manganese by ≥ 2 hours |
Phytate-Rich Foods (e.g., grains) | Phytates can bind Mn and reduce bioavailability | Consume Mn supplements separate from high-phytate meals |
Excess Calcium | Very high calcium may impair Mn uptake | Maintain balanced Ca:Mn ratio; follow label dosage |
Chronic Liver Disease | Mn clearance may be reduced, risking accumulation | Consult healthcare provider before supplementing |
Excessive Manganese Intake | > 11 mg/day can lead to neurological effects | Do not exceed recommended dosage without medical advice |
Third Party NABL Lab Report

Ask our expert, which supplement is best for you.
HealthyHey Manufacturing to Shipping
Highest Quality Control
Lab Report Manganese Gluconate
Download the Lab ReportScientific Paper of Manganese Gluconate
Questions & Answers
Have a Question?
Be the first to ask a question about this.