LongeviT - L-Ergothioneine - Known as Live-Longer Supplements - 30 Vegetable Capsules
100% Honest Claims with No False Promise.
Key Health Benefits
| Benefit Area | Study Summary | Model/Dosage | PubMed Link |
|---|---|---|---|
| Antioxidant & Cytoprotective Effects | Knocking down the ergothioneine transporter in cells led to heightened oxidative damage (mtDNA, protein, lipid oxidation), while EGT supplementation protected against oxidative stress. Notably, EGT scavenged superoxide as effectively as glutathione. | In vitro (HeLa cells with OCTN1 transporter knockdown; EGT tested against a superoxide generator) | PubMed |
| Mitochondrial Function & Energy | Exercise studies showed EGT accumulates in muscle mitochondria and directly activates the mitochondrial enzyme MPST. This interaction boosted mitochondrial respiration and improved exercise endurance in mice, revealing an EGT-driven mechanism for enhanced energy metabolism. | Animal study (mice undergoing endurance exercise; EGT identified as a key muscle mitochondrial factor) | PubMed |
| Skin Health & Photoaging Protection | Sub-micromolar EGT protected human skin cells from UV-induced damage by inhibiting AP-1 signaling and MMP-1 (collagenase) upregulation while activating Nrf2 antioxidant genes. These effects preserved collagen and mitigated oxidative stress, ultimately ameliorating UVA-induced skin aging markers. | Cell culture (human dermal fibroblasts); EGT 0.125–0.5 μM under UVA exposure | PubMed |
| Immune System Support | EGT exhibits anti-inflammatory immunomodulation. In LPS-challenged immune cells, EGT dose-dependently lowered proinflammatory cytokines (e.g. IL-1β, TNF-α, COX-2) and shifted macrophages from pro-inflammatory M1 toward anti-inflammatory M2 phenotype. In vivo, EGT treatment in a mouse psoriasis model reduced skin inflammation via downregulating the NF-κB/STAT3 pathway. | Animal + in vitro (imiquimod-induced psoriasis in mice; LPS-treated RAW264.7 macrophages and HaCaT keratinocytes with EGT) | PubMed |
| Neuroprotective or Cardiovascular | Neuroprotective: A randomized trial in older adults with mild cognitive impairment found that one year of EGT supplementation led to improved memory (better learning test scores) and prevented the rise of a neuronal injury marker (neurofilament light) compared to placebo. These results suggest EGT can enhance cognitive function and slow neurodegeneration. (EGT’s cardiovascular benefits are also noted in epidemiology, with higher plasma ergothioneine linked to lower coronary and mortality risk.) | Human trial (60+ year-old MCI patients; 25 mg EGT, thrice weekly for 12 months) | PubMed |
Dosage Recommendation
| Goal | Capsules per Day |
|---|---|
| General Antioxidant Support | 1 capsule daily with a meal |
| Skin Hydration & Elasticity | 1 capsule daily, ideally with breakfast |
| Immune & Anti-Inflammatory | 1 capsule daily, with lunch |
| Mitochondrial & Energy Support | 1 capsule daily, preferably before exercise |
| Vascular & Circulation Health | 1 capsule daily, with dinner |
Supplement Facts
NUTRITIONAL INFORMATION | |||
| Serving Size: 1 veg. Capsule | |||
| Amt. per Serving | % RDA Men | % RDA Women | |
| L-Ergothioneine | 5mg | ||
| Ingredients: L-L-Ergothioneine, Bulking Agent (INS 460 0), Anticaking Agent (INS 551) & Vegetable Capsule Shell (HPMC) (INS) | |||
What Research Says about L-Ergothioneine
L-Ergothioneine (ET) is a naturally occurring antioxidant compound found in various dietary sources such as mushrooms, certain plants, and some animal tissues. Research suggests several potential benefits associated with L-Ergothioneine supplementation:
Antioxidant Properties: L-Ergothioneine is a potent antioxidant that helps neutralize harmful free radicals in the body. Free radicals can damage cells and contribute to various diseases, including cardiovascular diseases, cancer, and neurodegenerative disorders.
Protective Effects on Cells: Studies have shown that L-Ergothioneine can protect cells from oxidative stress-induced damage. This protection may help maintain cellular function and integrity, promoting overall health and longevity.
Anti-inflammatory Effects: Chronic inflammation is linked to the development of many diseases, including arthritis, cardiovascular diseases, and certain cancers. L-Ergothioneine has been found to possess anti-inflammatory properties, which may help reduce inflammation and its associated health risks.
Neuroprotective Effects: There is growing evidence suggesting that L-Ergothioneine may have neuroprotective properties. Research indicates that it could help protect nerve cells from damage caused by oxidative stress and inflammation, potentially reducing the risk of neurodegenerative diseases such as Alzheimer's and Parkinson's.
Skin Health: Some studies suggest that L-Ergothioneine may benefit skin health. It has been proposed that L-Ergothioneine supplementation could help protect skin cells from UV-induced damage and oxidative stress, potentially reducing the risk of premature aging and skin disorders.
Cardiovascular Health: Preliminary research indicates that L-Ergothioneine may have beneficial effects on cardiovascular health. It has been suggested that its antioxidant and anti-inflammatory properties could help protect blood vessels from damage and reduce the risk of heart disease and stroke.
While these potential benefits are promising, more research is needed to fully understand the mechanisms of action and the specific health outcomes associated with L-Ergothioneine supplementation. Additionally, individual responses to supplementation may vary, and it's essential to consult with a healthcare professional before starting any new supplement regimen.
When Will I See Results?
| Outcome | Expected Timeline |
|---|---|
| Improved Antioxidant Markers | 2–4 weeks |
| Enhanced Skin Hydration & Elasticity | 4–6 weeks |
| Reduced Inflammation | 4–8 weeks |
| Boosted Energy & Endurance | 3–6 weeks |
| Better Vascular Function | 6–12 weeks |
How to Maximize Results
| Goal | Synergistic Stack & Tips |
|---|---|
| Antioxidant Defense | L-Ergothioneine + Vitamin C (500 mg) + Selenium (55 µg) |
| Skin & Photoprotection | L-Ergothioneine + Collagen Peptides + Daily broad-spectrum SPF |
| Immune & Inflammation | L-Ergothioneine + Omega-3 (EPA/DHA) + Turmeric (Curcumin 500 mg) |
| Mitochondrial & Energy | L-Ergothioneine + CoQ₁₀ (100 mg) + Magnesium (200 mg) |
| Vascular & Circulation | L-Ergothioneine + Garlic Extract + Regular aerobic exercise |
What to Avoid
| Substance/Condition | Why to Avoid | Advice |
|---|---|---|
| High-Dose Iron or Aluminum | May compete with EGT for OCTN1 transport into cells | Space dosing by ≥2 hours |
| Excessive Alcohol | Increases systemic oxidative stress, potentially counteracting EGT benefits | Limit intake |
| Unprotected UV Exposure | Physical sun damage can exceed EGT’s photoprotective capacity—always use topical SPF | Combine with daily sun protection |
| Chronic Sleep Deprivation & Stress | Heightens oxidative load and inflammation | Prioritize sleep hygiene and stress management |
Third Party NABL Lab Report
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Questions & Answers
Have a Question?
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Is it help to get good sleep during night.
Yes, HealthyHey's LongeviT may help mitigate stress-induced sleep disturbances, including those linked to depression and enhance overall sleep quality. -
Can CKD patients use it ?
HealthyHey's LongeviT may offer potential benefits for Chronic kidney disease (CKD) patients due to its antioxidant properties that help reduce oxidative stress, which is often elevated in CKD patients and can contribute to kidney damage. However, it's important for individuals to consult with their doctor before taking this product as it may interact with medications and health conditions.