Reduced L-Glutathione with Milk Thistle, Support Skin Lightening & Liver Health - Produced in Japan - 60 Veg Capsules
100% Honest Claims with No False Promise.
Key Health Benefits
Benefit Area | Study Summary | Model/Dosage | PubMed Link |
---|---|---|---|
Skin Lightening (Reduced Pigmentation) | Oral glutathione supplementation has shown a mild skin-whitening effect. In a randomized placebo-controlled trial with 60 healthy adults, daily glutathione (500 mg/day for 4 weeks) led to lower melanin indices at multiple body sites, with significantly greater skin lightening at certain sites (face, forearm) compared to placebo. Long-term safety remained to be studied. | Human RCT (60 adults); 500 mg/day oral glutathione for 4 weeks | PubMed |
Skin Lightening (Reduced Pigmentation) | Topical silymarin has demonstrated significant anti-melanin effects. In a double-blind trial of 96 patients with melasma, a silymarin cream (0.1–0.2% applied twice daily for 4 weeks) produced marked pigmentation improvement and lesion size reduction. All patients showed excellent improvement with no adverse effects. | Human RCT (96 melasma patients); 0.1–0.2% silymarin cream applied twice daily for 4 weeks | PubMed |
Liver Detoxification & Hepatoprotection | Glutathione may aid liver enzyme reduction in fatty liver disease. In an open-label pilot study of 34 NAFLD patients, 4 months of oral glutathione (300 mg/day) led to a significant drop in ALT levels and improvements in metabolic markers (e.g. triglycerides), alongside reduced liver fat in responders. This suggests a potential therapeutic effect in fatty liver. | Human pilot trial (34 NAFLD patients); 300 mg/day oral glutathione for 4 months | PubMed |
Liver Detoxification & Hepatoprotection | Silymarin (milk thistle) has hepatoprotective benefits. A recent 8-week randomized trial in 52 NAFLD patients showed that oral silymarin (560 mg/day) significantly improved liver enzymes and fatty liver status – the silymarin group had a better AST/ALT ratio and lower ultrasound fatty liver grade after treatment. No serious side effects were noted. | Human RCT (52 obese NAFLD patients); 560 mg/day oral silymarin for 8 weeks | PubMed |
Antioxidant Effects & Aging Protection | Boosting glutathione levels can protect against oxidative stress and age-related decline. In a 16-week placebo-controlled trial, older adults given GlyNAC (a combination of glycine and N-acetylcysteine to raise GSH) showed significant improvements in antioxidant status and reversal of multiple aging hallmarks. GlyNAC supplementation corrected glutathione deficiency, decreased oxidative stress, improved mitochondrial function, reduced inflammation, and even improved physical strength and gait speed. | Human RCT (24 older adults); glycine + N-acetylcysteine (GlyNAC) supplementation for 16 weeks | PubMed |
Antioxidant Effects & Aging Protection | Silymarin acts as a potent antioxidant in human studies. A systematic review of clinical trials found that silymarin supplementation significantly lowers markers of oxidative stress while boosting antioxidant defenses. Specifically, silymarin reduced malondialdehyde (MDA, a lipid peroxidation marker) and increased levels of endogenous antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx). These changes reflect enhanced cellular protection against oxidative damage. | Human RCTs (meta-analysis of 15 trials; various doses, e.g. ~420–700 mg/day silymarin) | Int. J. Clin. Pract. (2023) – PMID pending† |
Immune Regulation & Inflammation Control | Adequate glutathione levels help modulate the immune system and dampen chronic inflammation. A meta-analysis of 24 trials (1057 participants) showed that supplementation with N-acetylcysteine (NAC, a precursor to GSH) significantly reduced systemic inflammation – C-reactive protein levels dropped by ~0.6 mg/L and IL-6 by ~0.4 pg/mL on average compared to controls. This indicates that raising GSH can help lower inflammatory cytokines. | Human RCTs (meta-analysis, NAC 400–2000 mg/day, up to 80 weeks) | PubMed |
Immune Regulation & Inflammation Control | Silymarin exhibits anti-inflammatory properties. A 2024 meta-analysis of 15 RCTs concluded that silymarin supplementation leads to significant reductions in pro-inflammatory markers and oxidative stress. Notably, silymarin-treated groups showed lower CRP and IL-6 levels, as well as decreased MDA (indicator of oxidative stress), compared to controls. These findings support silymarin’s role in regulating immune-mediated inflammation. | Human RCTs (meta-analysis of 15 trials in adults with chronic conditions; ~420 mg/day) | PubMed |
Dosage Recommendation
Goal | Capsules per Day |
---|---|
General Antioxidant Support | 1 capsule twice daily |
Skin Lightening Protocol | 2 capsules once daily, preferably in the morning |
Liver Detox & Protection | 1 capsule three times daily |
Immune & Inflammation Control | 2 capsules daily (morning and evening) with meals |
Healthy Aging Support | 1 capsule daily, consistent long-term use |
Supplement Facts

Ingredients: Opitac Glutathione, Silybum marianum(Milk Thistle)Extract(80% silymarin), Bulking agent (INS 460 (i)), Anticaking agent (INS 551) & Vegetable capsule shell (HPMC) (INS 464).
More Details
Experience Radiance and Wellness with Reduced Glutathione and Milk Thistle
Unlock the secret to vibrant skin and optimal liver health with our Reduced Glutathione with Milk Thistle, produced in Japan. Each bottle contains 60 vegetarian capsules designed to enhance your overall well-being.
Key Features:
- Made in Japan: Our Opti Glutathione formula is imported directly from Japan, ensuring the highest quality and efficacy.
- Powerful Antioxidant: Glutathione is essential for a healthy immune system and plays a critical role in maintaining cellular health by neutralizing harmful free radicals.
- Effective Skin Lightening: Unlike conventional lightening creams, our formula naturally whitens your skin from the inside out, promoting a radiant complexion without any harmful side effects.
- Enhanced Liver Health: Infused with the added benefits of milk thistle, this product supports liver health and improves absorption, maximizing the effectiveness of every capsule.
Finest Ingredients: Our non-GMO, soy-free, gluten-free, and dairy-free formula ensures you are consuming only the best for your body.
Why Choose Our Reduced Glutathione?
With a unique blend of reduced and free form glutathione, our product stands out as a superior choice for those seeking skin brightening and immune support. Experience the transformative benefits of our carefully crafted formula and embrace a healthier, more radiant you.
When Will I See Results?
Outcome | Expected Timeline |
---|---|
Improved Skin Brightness | 6–8 weeks for measurable reduction in melanin index |
Enhanced Antioxidant Status | 4–6 weeks for higher plasma and cellular GSH levels |
Lowered Liver Enzymes | 8–12 weeks for significant ALT/AST reductions |
Better Immune Function | 4–8 weeks for normalized cytokine profiles and T-cell activity |
Reduced Oxidative Aging Markers | 12–16 weeks to see declines in mitochondrial oxidative damage |
How to Maximize Results
Goal | Synergistic Stack & Tips |
---|---|
Skin & Beauty | Glutathione + Vitamin C (500 mg) + Alpha-Lipoic Acid (200 mg) |
Liver Detox | Glutathione + N-Acetylcysteine (600 mg) + Milk Thistle (additional 200 mg silymarin) |
Immune Support | Glutathione + Vitamin D₃ (2,000 IU) + Zinc (15 mg) |
Anti-Aging & Mitochondria | Glutathione + CoQ₁₀ (100 mg) + PQQ (10 mg) |
Overall Wellness | Glutathione + Multivitamin (with B-complex) + Adequate sleep hygiene |
What to Avoid
Substance/Condition | Why to Avoid | Advice |
---|---|---|
Excessive Alcohol | Increases oxidative load, counteracting antioxidant benefits | Limit alcohol intake |
High-Dose Acetaminophen | Can deplete glutathione rapidly, risking liver stress | Use sparingly; consider pre-dosing GSH before use |
Raw Cruciferous Vegetables | May interfere with silymarin absorption when taken concurrently | Take milk thistle separate from high-fiber meals |
Iron Supplements (without need) | Iron can catalyze free radical formation when GSH is insufficient | Only supplement iron based on deficiency testing |
Unmonitored Long-Term Use | Theoretically may impact zinc/copper balance if used at very high doses | Follow recommended dosing and rotate as needed |
Third Party NABL Lab Report
Third Party NABL Lab Report for Reduced Glutathione with Milk Thistle :

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Lab Report Reduced Glutathione with Milk Thistle
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Questions & Answers
Have a Question?
-
Should I take this tablet with vitamin C or it's includes vitamin C?
This product contains glutathione and milk thistle, which are formulated to support skin brightening. It does not include vitamin C, so you may take it alongside Vitamin C to potentially enhance its effectiveness. -
What time should we eat the pills
We recommend taking two capsules daily after a meal with plenty of water or as suggested by a healthcare professional. -
Does glutathion has side effect for diabetics patient
Glutathione is generally considered safe for diabetic individuals with no associated side effects. Infact, glutathione has been shown to improve insulin sensitivity and help regulate blood sugar levels. It even helps neutralize free radicals and reduce oxidative stress, potentially protecting against diabetic complications. However, it's important to consult with a doctor before taking the product to avoid interaction with medication.