Key Health Benefits

Benefit	Description	PubMed Link
Homocysteine reduction	TMG (betaine) provides methyl groups (via the BHMT enzyme) to convert homocysteine into methionine, markedly lowering plasma homocysteine. In healthy adults, a meta‐analysis found ≥4 g/day betaine lowers homocysteine by ~1.2 μmol/L. In a controlled trial, combining 4 g TMG with folate and B12 reduced homocysteine by ~24%. This demonstrates that TMG (with B12) effectively supports one-carbon metabolism to clear homocysteine.	PMID: 31408467
Cardiovascular support	By lowering homocysteine, TMG/B12 may reduce atherosclerotic risk. In fact, reviews note betaine “improves vascular risk factors” (e.g. liver and vascular health) via methylation. However, several trials found high-dose TMG raises LDL and total cholesterol, which could offset benefits. Thus, while TMG+B12 improves homocysteine‐driven CV risk, its net effect on lipids is mixed.	PMID: 15916468
Methylation & detox support	TMG is a key methyl donor in the liver/kidneys, maintaining S-adenosylmethionine (SAM) and preventing hypomethylation. It remethylates homocysteine to methionine (via BHMT), supporting normal methylation in cells. Adequate methylation is critical for detox pathways and gene regulation; insufficient methyl donors cause elevated Hcy and fatty liver. Thus, TMG+B12 supplementation helps preserve healthy methylation status and clearance of toxic metabolites.	PMID: 15321791
Enhanced exercise performance	TMG has ergogenic effects on muscle performance. Human trials show betaine supplementation boosts strength and power. For example, 14 weeks of 2 g/day betaine increased athletes’ 1‑RM strength, VO₂max and sprint ability. Similarly, 6 weeks of 5 g/day betaine improved upper-body power and half-squat strength. These findings indicate TMG (+ B12 co-factors) can enhance endurance and power output in trained individuals.	PMID: 34663363
Mood & cognitive enhancement	TMG’s methyl donation supports brain methylation and SAMe synthesis. Elevated homocysteine is linked to cognitive decline, so TMG’s Hcy-lowering can be neuroprotective. Clinically, TMG has shown antidepressant synergy: one trial found SAMe + betaine improved depression more than SAMe alone. By aiding neurotransmitter methylation (with B12 and folate), TMG may thus enhance mood and cognitive resilience.	PMID: 25678811

Dosage Recommendation

Goal	Stack
Homocysteine Reduction	600 mg TMG + B12 daily (with breakfast); optionally stack with 400 mcg folate (5-MTHF) for enhanced methylation
Methylation & Detox Support	600 mg TMG + B12 daily; stack with 200 mcg selenium and 500 mg milk thistle extract for liver phase II detox enzyme activity
Cardiovascular Health	600 mg TMG + B12 daily; combine with 1 g omega-3 and 500 mg CoQ10 to reduce endothelial inflammation and support heart health
Exercise Performance & Recovery	1,000–2,500 mg TMG pre-workout; optionally combine with creatine monohydrate (3–5 g) and B12 for enhanced strength and ATP support
Mood & Cognitive Support	600 mg TMG + B12 daily (with breakfast); stack with 250 mg SAMe or 200 mg Rhodiola for additional mood-enhancing effects

Supplement Facts

NUTRITIONAL INFORMATION
Serving Size: 1 veg. Capsule
	Amt. per Serving	% RDA Men	% RDA Women
Betaine (Trimethylglycine)	600mg	**	**
Vitamin B12	2.2mcg	100	100
Ingredients: Betaine (Trimethylglycine), Bulking Agent INS 460 (i), Anticaking Agent (INS 341(iii)), Vitamin B12 & Vegetable Capsule Shell (HPMC) (INS 464)

More Details

Support homocysteine Levels
Support Liver Health

 

• HealthyHey Nutrition TMG trimethylglycine with Vitamin B12 - 600mg/serving - 60 vegetable capsules
• Support Homocysteine Levels
• Support Liver Health
• Manufactured at FSSAI, FSSC-22000, ISO-22000, GMP & USFDA registered Facility at Mumbai

 

Ingredients:

TMG trimethylglycine with Vitamin B12

When Will I See Results?

Goal	Expected Timeline
Homocysteine & Methylation Support	2 – 4 weeks for measurable reduction in homocysteine and improvement in methylation cycle efficiency
Detoxification & Liver Health	2 – 6 weeks for improved liver enzyme levels and detox biomarkers
Cardiovascular Markers	4 – 8 weeks for reduced arterial stiffness, homocysteine, and improved lipid-associated inflammation
Performance Enhancement	1 – 2 weeks for improved power output and reduced fatigue (especially with doses ≥ 2 g/day)
Mood & Neurological Function	2 – 4 weeks for better mood, motivation, and reduction in fatigue, especially in B12-deficient individuals

How to Maximise Results

Goal	Stack & Lifestyle Tips
Homocysteine Control	Take TMG with B12 and methylated folate (5-MTHF)Include leafy greens, beans, and fish in dietReduce alcohol, which impairs methylation
Exercise Recovery	Pair with protein (20–30 g) and electrolytesStay well hydratedUse post-training to reduce soreness and support muscle integrity
Mood & Cognitive Function	Ensure adequate sleep (7–8 hrs/night)Combine with adaptogens (e.g., Rhodiola) if under chronic stressAddress any B-vitamin deficiencies
Detoxification	Drink ≥2 L water/dayEat cruciferous vegetables to support liver enzymesLimit exposure to toxins (alcohol, smoking, BPA)

What to Avoid

Substance / Habit	Reason to Avoid	Spacing Tip
High-dose TMG (>3 g/day)	May increase LDL cholesterol in some individuals when used in excess	Stick to ≤2.5 g/day unless under medical supervision
Folate deficiency (no 5-MTHF)	Without adequate folate, TMG may not fully convert homocysteine to methionine	Ensure folate intake (400 mcg/day of methylfolate preferred)
Uncorrected B12 deficiency	TMG may worsen symptoms if B12 is low, as methylation demand increases	Always take with B12 (≥250–500 mcg/day)
Taking on Empty Stomach (Sensitive Users)	May cause mild nausea in some individuals	Take with food to improve absorption and reduce GI irritation
Alcohol & Smoking	Impairs methylation and depletes B-vitamin levels, negating TMG/B12 benefits	Limit alcohol; avoid smoking for optimal methylation health

Third Party NABL Lab Report

Third Party NABL Lab Report for TMG trimethylglycine with Vitamin B12 :

 

Click here to view the report