Key Health Benefits

Benefit	Description	PubMed Link
Antioxidant Capacity	L-histidine supplementation has been shown to enhance antioxidant defenses by increasing key antioxidant enzymes (e.g., superoxide dismutase, glutathione peroxidase) and reducing markers of oxidative stress in humans.	PubMed
Skin Health (Atopic Dermatitis)	Oral L-histidine can improve skin barrier function and significantly reduce atopic dermatitis severity. In a 4-week trial, daily L-histidine cut eczema severity by ~34–39%, likely by boosting filaggrin (skin barrier protein) production.	PubMed
Liver Detoxification (CKD)	In chronic kidney disease patients, L-histidine supplementation has demonstrated benefits for “detoxifying” excess toxins. It improved anemia treatment efficacy and limited oxidative damage from iron overload-induced stress. These effects are attributed to histidine’s ability to scavenge free radicals and chelate metal ions.	PubMed
Immune Modulation & Anti-Inflammatory	L-histidine exerts notable anti-inflammatory effects. For example, in obese individuals with metabolic syndrome, 12-week L-histidine supplementation significantly lowered circulating pro-inflammatory cytokines (TNF-α, IL-6), indicating a reduction in systemic inflammation.	PubMed

Dosage Recommendation

Goal	Stack
General Antioxidant Support	500 mg L-Histidine once daily with a meal
Skin Health & Barrier Repair	500 mg L-Histidine twice daily (morning and evening)
Liver Detoxification (CKD Context)	1 g L-Histidine daily, split into two 500 mg doses (morning and evening)
Immune Modulation & Anti-Inflammatory	500 mg L-Histidine twice daily (with breakfast and dinner); combine with 500 mg Vitamin C for added support
Respiratory & Mucolytic Support	1 g L-Histidine daily (500 mg morning, 500 mg evening); stack with 600 mg N-acetylcysteine once daily

Supplement Facts

NUTRITIONAL INFORMATION
Serving Size: 1 veg. Capsule
	Amt. per Serving	% RDA Men	% RDA Women
L-Histidine	550mg	**	**
Ingredients: L-Histidine, Bulking Agent INS 460 (i), Anticaking Agent (INS 341(iii)) & Vegetable Capsule Shell (HPMC) (INS 464).

More Details

Support Your Cognitive Health with L-Histidine

 

L-Histidine is a vital amino acid that plays a significant role in maintaining muscle support and enhancing cognitive function. Our L-Histidine capsules are specially formulated to provide optimal health benefits. Here's why you should consider adding this supplement to your daily routine:

 

Key Features:

 

• High Potency: Each serving delivers a powerful 1000 mg of L-Histidine to support your health needs.
• Free Form Amino Acid: Designed for maximum absorption and bioavailability.
• Purity Assured: Contains no yeast, dairy, egg, corn, soy, or wheat, making it suitable for various dietary restrictions.
• No Unwanted Additives: Free from sugar, starch, preservatives, and artificial colours, flavours, or fragrances.

• Manufactured with Care: Produced in a facility registered with FSSAI & USFDA, ensuring quality and safety.

   

Benefits:

 

• Muscle Support: L-Histidine is believed to play an important role in joint and muscle health.

• Cognitive Enhancement: Supports neurological function, aiding in cognitive health and mental clarity.

   

Choose HealthyHey L-Histidine for a reliable and effective way to support your cognitive health and muscle maintenance. Add this supplement to your regimen and experience the benefits of this essential amino acid!

When Will I See Results?

Goal	Expected Timeline
Antioxidant Capacity & Detoxification	1–2 weeks for measurable increases in plasma glutathione and reductions in oxidative biomarkers (e.g., MDA) in CKD or high-stress states.
Skin Health (Atopic Dermatitis)	4 weeks for initial reductions in eczema severity scores; 8 weeks for a ~30–50 % decrease in SCORAD or EASI scores as demonstrated in clinical studies.
Immune & Anti-Inflammatory Effects	4–6 weeks to observe lowered pro-inflammatory cytokines (e.g., IL-6, TNF-α) and improved markers of endothelial health in individuals with mild chronic inflammation.
Respiratory & Mucolytic (Not Evidenced)	No direct human evidence for L-histidine; mucolytic benefits are known for cysteine derivatives instead.

How to Maximise Results

Goal	Stack & Lifestyle Tips
Antioxidant & Detoxification	• Combine with N-acetylcysteine (600 mg) once daily for synergistic glutathione support.• Ensure adequate intake of sulfur-rich foods (garlic, onions) to support endogenous histidine availability.• Stay well-hydrated (≥ 2 L water/day).
Skin Health & Barrier Repair	• Pair with Zinc (250 mg) to support filaggrin processing and skin healing.• Use gentle, fragrance-free cleansers and apply emollients (ceramides) to lock in moisture.• Follow a balanced diet rich in essential fatty acids (e.g., fish oil).
Immune & Anti-Inflammatory	• Stack with Vitamin D₃ (400 IU) and Vitamin C (500 mg) daily to modulate cytokine profiles.• Moderate regular exercise (150 min/week) to improve vascular function.• Practice stress management (mindfulness, adequate sleep).

What to Avoid

Substance / Habit	Reason to Avoid	Spacing Tip
High-Dose L-Histidine (> 4 g/day without supervision)	Doses above 4 g/day can cause decreased serum zinc, potential cognitive changes, and gastrointestinal discomfort; long-term safety not established beyond 8 weeks in adults.	Consult a healthcare provider before exceeding 1 g/day; monitor zinc status if higher doses are used.
Concurrent Zinc Deficiency	Zinc and histidine compete for absorption; low zinc status can impair histidine metabolism and immune benefits; excess histidine can further deplete zinc.	Ensure adequate zinc intake (8–11 mg/day); space histidine and zinc supplements by ≥ 2 hours.
Empty Stomach (If Sensitive)	Some individuals may experience mild gastric discomfort or nausea when taking high doses of free amino acids on an empty stomach.	Take L-histidine with meals or a small snack to minimize GI upset.
High-Protein Diet without Amino Acid Balance	Excessive dietary histidine without other essential amino acids can disrupt amino acid balance and lead to inefficient protein synthesis.	Maintain a balanced protein intake (1.0–1.2 g/kg/day) from varied sources (meat, dairy, legumes).
Renal Impairment (Severe CKD)	Impaired kidney function may reduce histidine clearance, risking accumulation and metabolic disturbances; caution in advanced CKD without medical oversight.	Use only under physician guidance if eGFR < 30 mL/min/1.73 m².

Third Party NABL Lab Report

Third Party NABL Lab Report for L-Histidine :

 

Click here to view the report