Key Health Benefits

Use Case	Summary of Findings	PubMed Link
Cartilage Matrix Repair & Structural Support	An OA rat model showed UC-II reduced cartilage degeneration (lower histological Mankin scores) and decreased cartilage breakdown markers, indicating a protective effect on cartilage structure.	PubMed
Joint Pain Reduction (Osteoarthritis)	In knee osteoarthritis patients, 90‑day UC-II supplementation significantly reduced pain (≈40% drop in VAS pain score) and overall symptoms (33% WOMAC score reduction), far outperforming glucosamine–chondroitin.	PubMed
Improved Mobility & Joint Flexibility	A 24-week trial in healthy adults with exercise-related joint discomfort found UC-II significantly increased knee range-of-motion (flexion +3.2° vs +0.2° in placebo) and improved extension, reflecting better joint flexibility.	PubMed
Anti-Inflammatory Effects (Cytokine Modulation)	UC-II has shown potent anti-inflammatory action in OA models – e.g. UC-II–fed rats had markedly lower levels of proinflammatory cytokines (IL-1β, IL-6, TNF-α) and catabolic mediators (CRP, MMP-3), along with suppressed PGE2 and NF-κB activity in joints.	PubMed
Joint Comfort & Reduced Soreness in Athletes	An RCT in healthy volunteers with exercise-induced knee pain showed that 40 mg UC-II daily improved knee joint extension, prolonged pain-free exercise duration, and reduced post-exertion joint pain compared to placebo.	PubMed

Dosage Recommendation

Goal/Use Case	Capsules per Day
General Wellness / Maintenance	1 capsule daily (meets RDA and prevents deficiency)
Energy & Fatigue Support	1 capsule daily, taken in the morning on an empty stomach for best absorption
Nervous System & Cognitive Support	1 capsule daily; those with neuropathy may consider 2 capsules daily under medical guidance
Cardiovascular (Homocysteine Management)	1 capsule daily, ideally alongside folate and B6 in a B-complex
Therapeutic Deficiency Correction	2 capsules daily (split morning and evening) or as directed by a healthcare provider for diagnosed deficiency

Supplement Facts

NUTRITIONAL INFORMATION
Serving Size: 1 Veg. Capsule
	Amt. per Serving	% RDA
Native/Undenatured Type II Collagen	40mg	**
Curcuma Longa Root Extract(5%)	50mg	**
Ingredients: Curcuma Longa Root Extract(5%), Native/Undenatured Type II Collagen, Bulking Agent (INS 460 (i)) & Vegetable Capsule Shell (HPMC) (INS 464)

When Will I See Results?

Outcome	Expected Timeline
Energy & Vitality	2–4 weeks for noticeable reduction in fatigue and improved energy levels
Red Blood Cell Health (Anemia)	4–8 weeks for significant improvement in hemoglobin and red cell indices
Neuropathy & Cognitive Function	8–12 weeks for gradual improvements in nerve symptoms and mental clarity; longer if damage is severe
Homocysteine Reduction	8–12 weeks to see meaningful decreases in plasma homocysteine on blood tests
Mood & Mental Clarity	4–8 weeks for improvements in mood stability, reduced brain fog, and enhanced cognitive performance

How to Maximize Results

Goal	Synergistic Stack & Tips
Anemia Prevention & RBC Support	Vitamin B12 + Folate (B9) + Iron + Vitamin C (enhances iron absorption)
Energy & Metabolism	Vitamin B12 + B-Complex (B1, B2, B3, B5, B6) + CoQ10
Nerve & Cognitive Health	Vitamin B12 + Vitamin B1 (Thiamine) + Vitamin B6 (Pyridoxine)
Cardiovascular Health (Homocysteine Control)	Vitamin B12 + Folate + Vitamin B6 in a dedicated homocysteine-lowering B-complex; plus regular physical activity and a diet rich in leafy greens and omega-3 fats
Mood & Mental Well-being	Vitamin B12 + Folate + Omega-3 (EPA/DHA) + Regular stress-management (e.g. meditation, adequate sleep)

What to Avoid

Substance/Factor	Why to Avoid	Advice
High-Dose Vitamin C (with B12)	Mega-doses of C can degrade B12 in the gut if taken simultaneously	Space high-dose vitamin C and B12 by at least 2 hours; dietary vitamin C is fine
Excessive Folic Acid without B12	Can mask B12 deficiency by correcting anemia but not neurological damage	Always ensure adequate B12 when supplementing folate; use combined B12-fortified formulas
Chronic Alcohol Use	Impairs B12 absorption through gastric mucosal damage	Limit alcohol; avoid taking B12 capsules with alcohol
PPI/Antacid Medications	Reduce stomach acidity, hindering B12 release from food-bound forms	Consider sublingual B12 or injections if on long-term acid-reducing therapy; space dosing
Metformin (Long-term Use)	Associated with reduced B12 absorption in the ileum	Monitor B12 levels if using metformin; may require higher oral doses or alternative formulations

Third Party NABL Lab Report

Third Party NABL Lab Report for NTC II Type 2 :

 

Click here to view the report